Cortistatin-29 (rat)

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Cortistatin-29 is a neuropeptide. Cortistatin-29 alleviates neuropathic pain. Cortistatin-29 binds all somatostatin (SS) receptor subtypes with high affinity and shows IC50 values of 2.8 nM, 7.1 nM, 0.2 nM, 3.0 nM, 13.7 nM for SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, respectively. Cortistatin-29 shows anti-fibrotic effects.

Cortistatin-29 is a neuropeptide. Cortistatin-29 alleviates neuropathic pain. Cortistatin-29 binds all somatostatin (SS) receptor subtypes with high affinity and shows IC50 values of 2.8 nM, 7.1 nM, 0.2 nM, 3.0 nM, 13.7 nM for SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, respectively. Cortistatin-29 shows anti-fibrotic effects.

Cortistatin 29 (1-2 μg) 可缓解小鼠慢性神经性疼痛。Cortistatin 29 (1 nmol/小鼠；腹腔注射；每周三次) 在小鼠中表现出抗纤维化作用。Animal Model:20-24 g body weight, 8-12 weeks-old mice Dosage:1 μg in 20 μL for s.c.; 2 μg in 200 μL for i.p.; 20 ng in 10 μL for i.t.Administration:Every other day for 12 days Result:Ameliorated hyperalgesia and allodynia, regulated the nerve damageinduced hypersensitization of primary nociceptors, inhibited neuroinflammatory responses, and enhanced the production of neurotrophic factors both at the peripheral and central levels.

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Others

Other Targets

SSTR1: 2.8 nM (IC50), SSTR2: 7.1 nM (IC50), SSTR3: 0.2 nM (IC50), SSTR4: 3.0 nM (IC50), SSTR5: 13.7 nM (IC50)]

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1815618-17-7

3540.09

C161H240N46O41S2

>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years